Hyperlipidemia is a common cardiovascular disease, which is closely related to atherosclerosis and the occurrence and development of cardiovascular and cerebrovascular diseases. With the improvement of living standards of contemporary people and the change of diet structure, the prevalence of hyperlipidemia is increasing, which also leads to chronic diseases such as cardiovascular and cerebrovascular diseases, diabetes, obesity and so on. The research and exploration of hyperlipidemia animal model has become a hot spot in the research of cardiovascular and cerebrovascular diseases, diabetes and other diseases.

A rat model of hyperlipidemia

A mouse model of hyperlipidemia

Observation indicators

Body weight, serum TC, TG, LDL-c significantly increased, while HDL-c significantly decreased;